ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SMMA................*JBDM Ver 2.0.16 (1th of February 2022) - 2999001/03894393CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120230215W172 73deBibliographieenBibliographyfrBibliographieEP19835312.02019121320210709enenen20182045020181214GB2023021520230720211020202142202212212022512022072520230215202307C07D 239/36 19740701AFI20200619BHEP A61K 31/513 20000101ALI20200619BHEP A61P 1/16 20000101ALI20200619BHEP A61P 11/06 20000101ALI20200619BHEP A61P 11/08 20000101ALI20200619BHEP C07D 239/36 20130101 FI20200213BHEP A61P 11/06 20180101 LI20200213BHEP A61P 11/08 20180101 LI20200213BHEP A61P 1/16 20180101 LI20200213BHEP A61K 31/513 20130101 LI20200306BHEP dePYRIMIDONE VERBINDUNGEN UND DEREN VERWENDUNG ZUR BEHANDLUNG VON ALPHA-1-ANTITRYPSIN-MANGELenPYRIMIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA-1-ANTITRYPSIN DEFICIENCYfrCOMPOSÉS DE PYRIMIDONE ET LEUR UTILISATION DANS LE TRAITEMENT D'UNE DÉFICIENCE EN ALPHA-1-ANTITRYPSINEWO-A2-01/52830WO-A2-2008/143633US-A1- 2015 045 344MEERA MALLYA ET AL: "Small Molecules Block the Polymerization of Z [alpha] 1 -Antitrypsin and Increase the Clearance of Intracellular Aggregates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, no. 22, 1 November 2007 (2007-11-01), pages 5357-5363, XP55667904, US ISSN: 0022-2623, DOI: 10.1021/jm070687zMARION BOUCHECAREILH ET AL: "Histone Deacetylase Inhibitor (HDACi) Suberoylanilide Hydroxamic Acid (SAHA)-mediated Correction of [alpha]1-Antitrypsin Deficiency", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 45, 2 November 2012 (2012-11-02), pages 38265-38278, XP55667908, US ISSN: 0021-9258, DOI: 10.1074/jbc.M112.404707RAMSDEN, NigelRxCelerate Limited The Dorothy Hodgkin Building Babraham Research CampusBabraham, Cambridge CB22 3FHGBFOX, David JohnDepartment of Chemistry The University of Warwick Gibbet Hill RoadCoventry CV4 7ALGBHUNTINGTON, James Andrewc/o Z Factor Limited 3rd Floor 1 Ashley RoadAltrincham, Cheshire WA14 2DTGBZ Factor Limited101953348P/79561.EP01/MR3rd Floor 1 Ashley RoadAltrincham Cheshire WA14 2DTGBRoberts, Michael Austin101315962Reddie & Grose LLP The White Chapel Building 10 Whitechapel High StreetLondon E1 8QSGBALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTRMA20210709GB201905355220191213enWO202012099220200618202025