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EP 3 897 570 A1

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(43) Date of publication: 27.10.2021 Bulletin 2021/43 (21) Application number: 19829134.6 (22) Date of filing: 18.12.2019

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 38/26(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/0019; A61K 38/26 (86) International application number: PCT/EP2019/085942 (87) International publication number: WO 2020/127476 (25.06.2020 Gazette 2020/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.12.2018 SI 201800275 12.09.2019 SI 201900172 (71) Applicant: KRKA, d.d., Novo mesto 8501 Novo mesto (SI)

(72) Inventors: ROZMAN, Sasa 8270 Krsko (SI) KOLESA DOBRAVC, Tanja 8311 Kostanjevica na Krki (SI) SLADIC, Gordan 8000 Novo Mesto (SI) VIDIC, Iztok 1000 Ljubljana (SI) LIN, Haowen Shenzhen Hi-tech Industrial Park 518057 Guangdong (CN) HE, Guotao Shenzhen Hi-tech Industrial Park 518057 Guangdong (CN) QIN, Liangzheng Shenzhen Hi-tech Industrial Park 518057 Guangdong (CN) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)