(19)

(11)

EP 3 898 972 A1

(12)

(43) Date of publication: 27.10.2021 Bulletin 2021/43 (21) Application number: 19818190.1 (22) Date of filing: 18.12.2019

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) C12N 15/10(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/465; C12N 15/102; C12N 15/90; A61K 48/00; C12N 15/1135; C12N 2310/20 (86) International application number: PCT/EP2019/085957 (87) International publication number: WO 2020/127487 (25.06.2020 Gazette 2020/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.12.2018 EP 18215341 (71) Applicant: Aarhus Universitet 8000 Aarhus C (DK)	(72) Inventors: HOLM, Christian, Kanstrup 8520 Lystrup (DK) LUO, Yonglun 8250 Egå (DK) STOUGAARD, Magnus 8260 Viby J (DK) MØLLER, Charlotte, Thornild 8520 Lystrup (DK) NYEGAARD, Mette 9260 Gistrup (DK) (74) Representative: Plougmann Vingtoft a/s  Strandvejen 70 2900 Hellerup 2900 Hellerup (DK)