(19)

(11)

EP 3 902 813 A2

(12)

(88) Date of publication A3: 06.08.2020 (43) Date of publication: 03.11.2021 Bulletin 2021/44 (21) Application number: 19903962.9 (22) Date of filing: 22.12.2019

(51) International Patent Classification (IPC):  C07H 15/26(2006.01) C12N 15/113(2010.01) (52) Cooperative Patent Classification (CPC): A61K 47/60 (86) International application number: PCT/US2019/068205 (87) International publication number: WO 2020/139788 (02.07.2020 Gazette 2020/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.12.2018 US 201862786213 P (71) Applicants: Sirnaomics, Inc. Gaithersburg, MD 20879 (US) Zhang, Peter Suzhou 215125 (CN)	(72) Inventors: LU, Xiaoyong Gaithersburg, MD 20879 (US) EVANS, David, M. Gaithersburg, MD 20879 (US) LU, Patrick, Y. Gaithersburg, MD 20879 (US) LU, Alan Gaithersburg, MD 20879 (US) XU, John Gaithersburg, MD 20879 (US) ZHANG, Peter Suzhou 215125 (CN) (74) Representative: Danner, Stefan  Danner BioPharm IP Ludwigstraße 8 80539 München 80539 München (DE)