(19)

(11)

EP 3 906 052 A1

(12)

(43) Date of publication: 10.11.2021 Bulletin 2021/45 (21) Application number: 20702946.3 (22) Date of filing: 03.01.2020

(51) International Patent Classification (IPC):  A61K 39/245(2006.01) A61P 35/00(2006.01) A61P 17/00(2006.01) A61P 25/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/245; A61K 2039/5254; A61K 2039/55; A61K 2039/70; A61P 17/00; A61P 25/00; A61P 35/00; A61K 2039/844; A61K 2039/892 (86) International application number: PCT/US2020/012170 (87) International publication number: WO 2020/142677 (09.07.2020 Gazette 2020/28)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.01.2019 US 201916238933 (71) Applicant: Albert Einstein College of Medicine Bronx, NY 10461 (US)	(72) Inventors: HEROLD, Betsy Rowayton, CT 06853 (US) JACOBS Jr., William Pelham, NY 10803 (US) GONZALEZ-MUNOZ, Pablo A. Santiago, 7500000 (CL) PETRO, Christopher Pleasanton, CA 94566 (US) (74) Representative: De Clercq & Partners  Edgard Gevaertdreef 10a 9830 Sint-Martens-Latem 9830 Sint-Martens-Latem (BE)