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(11)

EP 3 924 973 A1

(12)

(43) Date of publication: 22.12.2021 Bulletin 2021/51 (21) Application number: 20754956.9 (22) Date of filing: 14.02.2020

(51) International Patent Classification (IPC):  G16B 25/00(2019.01) C12Q 1/6813(2018.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6883; C12Q 2600/158; G16B 40/20; G16B 20/00 (86) International application number: PCT/US2020/018297 (87) International publication number: WO 2020/168196 (20.08.2020 Gazette 2020/34)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.02.2019 US 201916276420 (71) Applicants: University of North Texas Health Science Center at Fort Worth Fort Worth, TX 76107 (US) Board of Regents, The University of Texas System Austin, TX 78701 (US)

(72) Inventors: O'BRYANT, Sid, E. Aledo, TX 76008 (US) BARBER, Robert, C. Benbrook, TX 76126 (US) XIAO, Guanghua Coppell, TX 75019 (US) GERMAN, Dwight Dallas, TX 75225 (US) (74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB  Leopoldstraße 4 80802 München 80802 München (DE)