| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
28.02.2019 US 201962811575 P
|
| (43) |
Date of publication of application: |
|
05.01.2022 Bulletin 2022/01 |
| (73) |
Proprietors: |
|
- The Rockefeller University
New York, NY 10065 (US)
- Inspirna, Inc.
Long Island City, NY 11101 (US)
|
|
| (72) |
Inventors: |
|
- TAVAZOIE, Sohail F.
New York, NY 10065 (US)
- OSTENDORF, Benjamin N.
New York, NY 10021 (US)
- TAVAZOIE, Masoud
New York, NY 10065 (US)
- GONSALVES, Foster
Brooklyn, NY 11238 (US)
|
| (74) |
Representative: Barker Brettell LLP |
|
100 Hagley Road
Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB) |
| (56) |
References cited: :
WO-A1-2015/065505 WO-A1-95/16791 WO-A2-2017/181163 CN-A- 109 251 974 US-A1- 2006 160 079 US-A1- 2015 065 515 US-A1- 2017 066 791
|
WO-A1-2017/161188 WO-A2-2014/028461 CN-A- 108 738 323 US-A- 5 945 289 US-A1- 2012 231 457 US-A1- 2015 150 941 US-A1- 2018 072 810
|
|
| |
|
|
- BENN MARIANNE ET AL: "Low-Density Lipoprotein Cholesterol and the Risk of Cancer:
A Mendelian Randomization Study", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 103,
no. 6, 1 February 2011 (2011-02-01), GB, pages 508 - 519, XP055972059, ISSN: 0027-8874,
DOI: 10.1093/jnci/djr008
- SPEIDELL ANDREW P ET AL: "Development of a HumanAPOEKnock-in Mouse Model for Study
of Cognitive Function After Cancer Chemotherapy", NEUROTOXICITY RESEARCH, HARWOOD
ACADEMIC PUBLISHERS, LAUSANNE, CH, vol. 35, no. 2, 4 October 2018 (2018-10-04), pages
291 - 303, XP036674838, ISSN: 1029-8428, [retrieved on 20181004], DOI: 10.1007/S12640-018-9954-7
- CHANG N W ET AL: "Apolipoprotein E4 allele influences the response of plasma triglyceride
levels to tamoxifen in breast cancer patients", CLINICA CHIMICA ACTA, ELSEVIER BV,
AMSTERDAM, NL, vol. 401, no. 1-2, 1 March 2009 (2009-03-01), pages 144 - 147, XP025898593,
ISSN: 0009-8981, [retrieved on 20081211], DOI: 10.1016/J.CCA.2008.12.005
- SIMONS KARIN H ET AL: "T cell co-stimulation and co-inhibition in cardiovascular disease:
a double-edged sword", NATURE REVIEWS CARDIOLOGY, NATURE PUBLISHING GROUP, GB, vol.
16, no. 6, 15 February 2019 (2019-02-15), pages 325 - 343, XP036784140, ISSN: 1759-5002,
[retrieved on 20190215], DOI: 10.1038/S41569-019-0164-7
- FYMAT ALAIN: "Harnessing the Immune System to Treat Cancers and Neurodegenerative
Diseases", 4 April 2018 (2018-04-04), XP055853404, Retrieved from the Internet <URL:https://asclepiusopen.com/clinical-research-in-neurology/volume-1-issue-1/8.pdf>
[retrieved on 20211021]
- YANG ET AL.: "Causal relevance of circulating high-density lipoprotein cholesterol
with cancer: a Mendelian randomization meta-analysis", SCI REP, vol. 5, no. 9495,
30 March 2015 (2015-03-30), pages 9495, XP055764108
- TAVAZOIE ET AL.: "LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer",
CELL, vol. 172, no. 4, 11 January 2018 (2018-01-11), pages 825 - 840, XP085347108
- VERGHESE ET AL.: "ApoE influences amyloid-.beta. (A.beta.) clearance despite minimal
apoE/A.beta. association in physiological conditions", PROCEEDINGS OF THE NATIONAL
ACADEMY OF SCIENCES, vol. 110, no. 19, 7 May 2013 (2013-05-07), pages E1807 - E1816,
XP055485641
|
|