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EP 3 934 669 A1

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(43) Date of publication: 12.01.2022 Bulletin 2022/02 (21) Application number: 20767438.3 (22) Date of filing: 05.03.2020

(51) International Patent Classification (IPC):  A61K 35/17(2015.01) C07K 16/30(2006.01) C12N 5/0783(2010.01) C07K 14/705(2006.01) C07K 16/46(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2863; A61P 35/04; A61K 2039/884; A61K 39/001195; A61K 2039/5156; C07K 2319/33; C07K 14/70578; C07K 16/2827; A61K 35/17; C07K 2319/03; C07K 14/70517; A61K 2039/5158; A61K 31/661; A61K 31/7076; A61K 38/00; C07K 16/2818; C07K 16/3069; C07K 2319/32; A61P 35/00; C07K 2317/622; C07K 14/70521; C07K 2317/31; C07K 14/7051 (86) International application number: PCT/US2020/021205 (87) International publication number: WO 2020/181094 (10.09.2020 Gazette 2020/37)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 05.03.2019 WO PCT/US2019/020729 (71) Applicant: The Trustees of the University of Pennsylvania Philadelphia, PA 19104 (US)	(72) Inventors: ZHAO, Yangbing Lumberton, New Jersey 08048 (US) LIN, Szu Hua Sharon Philadelphia, Pennsylvania 19104 (US) LIU, Xiaojun Wallingford, Pennsylvania 19086 (US) CHEW, Anne Cherry Hill, New Jersey 08003 (US) (74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB  Leopoldstraße 4 80802 München 80802 München (DE)