(19)

(11)

EP 3 935 167 A2

(12)

(88) Date of publication A3: 29.10.2020 (43) Date of publication: 12.01.2022 Bulletin 2022/02 (21) Application number: 20770560.9 (22) Date of filing: 09.03.2020

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) A61K 31/7088(2006.01) C12N 15/113(2010.01) A61K 47/54(2017.01) (52) Cooperative Patent Classification (CPC): C12N 2310/14; C12N 15/113; C12N 2310/11; C12N 2310/3519 (86) International application number: PCT/US2020/021652 (87) International publication number: WO 2020/185651 (17.09.2020 Gazette 2020/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.03.2019 US 201962815647 P (71) Applicants: Rutgers, the State University of New Jersey New Brunswick, NJ 08901 (US) Silagene, Inc. Hillsborough, NJ 08844 (US)

(72) Inventors: GUNDERSON, Samuel, Ian Piscataway, NJ 08854 (US) GORACZNIAK, Rafal Hillsborough, NJ 08844 (US) (74) Representative: Hobson, David James et al Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG London SE1 9SG (GB)