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EP 3 938 374 A2

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(88) Date of publication A3: 22.10.2020 (43) Date of publication: 19.01.2022 Bulletin 2022/03 (21) Application number: 20720117.9 (22) Date of filing: 16.03.2020

(51) International Patent Classification (IPC):  C07H 13/04(2006.01) C07H 15/04(2006.01) A61K 31/7028(2006.01) A61P 31/04(2006.01) A61P 33/00(2006.01) C07H 13/08(2006.01) A61K 31/7024(2006.01) A61P 31/00(2006.01) A61P 31/10(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/04; C07H 13/04; Y02A 50/30; A61K 31/7024; A61P 33/00; A61P 31/10; A61P 35/00; A61P 31/00 (86) International application number: PCT/IB2020/052378 (87) International publication number: WO 2020/183442 (17.09.2020 Gazette 2020/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.03.2019 PT 2019115367 (71) Applicants: UNIVERSIDADE NOVA DE LISBOA 1099-085 Lisboa (PT) Instituto Politécnico De Bragança 5300-253 Bragança (PT) Institute For Biological Research "Sinisa Stankovic" Belgrade, 11 000 (RU)

(72) Inventors: MARKOVA-PETROVA, Krasimira Todorova 2829-516 Caparica (PT) FERNANDES RODRIGUES FERREIRA, Isabel Cristina 5300-253 Bragança (PT) COSTA CALHELHA, Manuel Ricardo 5300-253 Bragança (PT) SOKOVIC, Marina Belgrade, 11 000 (RU) (74) Representative: Patentree  Edificio Net Rua de Salazares, 842 4149-002 Porto 4149-002 Porto (PT)