(19)

(11)

EP 3 941 531 A1

(12)

(43) Date of publication: 26.01.2022 Bulletin 2022/04 (21) Application number: 20777784.8 (22) Date of filing: 23.03.2020

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 2039/5154; C12N 15/88; A61K 2039/5152; A61K 2039/55555; A61K 39/39 (86) International application number: PCT/US2020/024220 (87) International publication number: WO 2020/198145 (01.10.2020 Gazette 2020/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 22.03.2019 US 201962822385 P (71) Applicant: The Johns Hopkins University Baltimore, Maryland 21218 (US)	(72) Inventors: GREEN, Jordan J. Baltimore, Maryland 21218 (US) TZENG, Stephany Yi Baltimore, Maryland 21218 (US) WILSON, David Baltimore, Maryland 21218 (US) MEYER, Randall A. Baltimore, Maryland 21218 (US) (74) Representative: Murgitroyd & Company  Murgitroyd House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)