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(11)

EP 3 947 731 A1

(12)

(43) Date of publication: 09.02.2022 Bulletin 2022/06 (21) Application number: 20815612.5 (22) Date of filing: 22.05.2020

(51) International Patent Classification (IPC):  C12Q 1/6869(2018.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6874   C-Sets: C12Q 1/6874, C12Q 2521/101, C12Q 2537/157, C12Q 2563/149; (86) International application number: PCT/US2020/034409 (87) International publication number: WO 2020/243017 (03.12.2020 Gazette 2020/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 24.05.2019 US 201962852876 P 06.09.2019 US 201962897172 P 23.09.2019 US 201916579794 (71) Applicant: Element Biosciences, Inc. San Diego, CA 92121 (US)

(72) Inventors: ARSLAN, Sinan San Diego, California 92121 (US) HE, Molly San Diego, California 92121 (US) KELLINGER, Matthew San Diego, California 92121 (US) LEVIEUX, Jake San Diego, California 92121 (US) PREVITE, Michael San Diego, California 92121 (US) ZHAO, Junhua San Diego, California 92121 (US) ZHANG, Su San Diego, California 92121 (US) LOPEZ, Tyler San Diego, California 92121 (US) (74) Representative: Avidity IP  Broers Building Hauser Forum 21 JJ Thomson Avenue Cambridge CB3 0FA Cambridge CB3 0FA (GB)