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(11)

EP 3 952 998 A1

(12)

(43) Date of publication: 16.02.2022 Bulletin 2022/07 (21) Application number: 20721371.1 (22) Date of filing: 08.04.2020

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07D 401/04(2006.01) C07D 491/107(2006.01) C07D 239/22(2006.01) C07D 403/04(2006.01) A61K 31/506(2006.01) (52) Cooperative Patent Classification (CPC): C07D 239/22; C07D 491/107; C07D 403/04; C07D 401/04; A61P 35/00 (86) International application number: PCT/US2020/027309 (87) International publication number: WO 2020/210384 (15.10.2020 Gazette 2020/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.04.2019 EP 19167897 29.07.2019 US 201962879816 P 26.03.2020 US 202063000257 P (71) Applicant: Merck Patent GmbH 64293 Darmstadt (DE)

(72) Inventors: JORAND-LEBRUN, Catherine Arlington, Massachusetts 02474 (US) BOIVIN, Roch Chelmsford, Massachusetts 01863 (US) JOHNSON, Theresa Salem, Massachusetts 01970 (US) WANG, Yanping Billerica, Massachusetts 01821 (US) XIAO, Yufang Lexington, Massachusetts 02421 (US) CHEN, Xiaoling Chestnut Hill, Massachusetts 02467 (US) LINDE, Nina 60325 Frankfurt am Main (DE) MUSCH, Doreen 64354 Reinheim (DE) KUMAR, Deepak Canton, Massachusetts 02021 (US)