(19)

(11)

EP 3 953 388 A1

(12)

(43) Date of publication: 16.02.2022 Bulletin 2022/07 (21) Application number: 20722422.1 (22) Date of filing: 08.04.2020

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12N 5/0783(2010.01) (86) International application number: PCT/US2020/027320 (87) International publication number: WO 2020/210392 (15.10.2020 Gazette 2020/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 09.04.2019 US 201962831572 P 02.10.2019 EP 19306261 (71) Applicant: SANOFI 75008 Paris (FR)

(72) Inventors: BIRKENFELD, Joerg 65926 Frankfurt am Main (DE) NABEL, Gary J. Bridgewater, New Jersey 08807 (US) QIU, Huawei Westborough, Massachusetts 01581 (US) REGULA, Joerg 81377 Munich (DE) SEUNG, Edward Bridgewater, New Jersey 08807 (US) WEI, Ronnie Bridgewater, New Jersey 08807 (US) WU, Lan Bridgewater, New Jersey 08807 (US) XING, Zhen Bridgewater, New Jersey 08807 (US) XU, Ling Bridgewater, New Jersey 08807 (US) PRADES, Catherine 75008 Paris (FR) DABDOUBI, Tarik 75008 Paris (FR) CAMERON, Béatrice 75008 Paris (FR) LEMOINE, Cendrine 75008 Paris (FR) YANG, Zhi-Yong Bridgewater, New Jersey 08807 (US) (74) Representative: Lavoix  Bayerstraße 83 80335 München 80335 München (DE)