(19)

(11)

EP 3 962 498 A1

(12)

(43) Date of publication: 09.03.2022 Bulletin 2022/10 (21) Application number: 20798058.2 (22) Date of filing: 30.04.2020

(51) International Patent Classification (IPC):  A61K 35/17(2015.01) C12N 5/10(2006.01) C07K 16/30(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/17; C07K 16/2878; C07K 2317/622; A61K 2039/505; A61K 2039/5156; C07K 2319/03; C07K 14/7051; C07K 2319/33; A61P 35/00; A61K 39/3955; A61K 39/001117   C-Sets: A61K 39/3955, A61K 2300/00; A61K 39/001117, A61K 2300/00; (86) International application number: PCT/US2020/030690 (87) International publication number: WO 2020/223470 (05.11.2020 Gazette 2020/45)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 30.04.2019 US 201962840906 P (71) Applicant: Memorial Sloan Kettering Cancer Center New York, NY 10065 (US)	(72) Inventors: SMITH, Eric, L. New York, NY 10065 (US) BRENTJENS, Renier, J. New York, NY 10065 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)