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EP 3 963 094 A1

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(43) Date of publication: 09.03.2022 Bulletin 2022/10 (21) Application number: 20799450.0 (22) Date of filing: 28.04.2020

(51) International Patent Classification (IPC):  C12Q 1/68(2018.01) G16B 40/00(2019.01) G01N 33/50(2006.01) G06N 20/00(2019.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6883; C12Q 2600/178; G06N 20/20; G16B 40/20; G16B 20/00; G16B 25/10; G06K 9/6269; G06K 9/6282; G06K 9/6276; G06K 9/6278; G06K 9/6265 (86) International application number: PCT/US2020/030284 (87) International publication number: WO 2020/223238 (05.11.2020 Gazette 2020/45)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.04.2019 US 201962840300 P 31.10.2019 WO PCT/US2019/059006 (71) Applicants: Yale University New Haven, CT 06510 (US) Dot Laboratories, Inc. Branford, CT 06405 (US)

(72) Inventors: TAYLOR, Hugh New Haven, Connecticut 06510 (US) BOWERMAN, Heather Branford, Connecticut 06405 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)