(19)

(11)

EP 3 969 467 A2

(12)

(88) Date of publication A3: 24.12.2020 (43) Date of publication: 23.03.2022 Bulletin 2022/12 (21) Application number: 20810804.3 (22) Date of filing: 18.05.2020

(51) International Patent Classification (IPC):  C07K 14/62(2006.01) A61P 3/10(2006.01) A61K 38/28(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/62; A61P 7/12 (86) International application number: PCT/US2020/033493 (87) International publication number: WO 2020/236762 (26.11.2020 Gazette 2020/48)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 17.05.2019 US 201962849363 P (71) Applicant: CASE WESTERN RESERVE UNIVERSITY Cleveland, Ohio 44106 (US)	(72) Inventors: WEISS, Michael A. Indianapolis, Indiana 46204 (US) GLIDDEN, Michael D., II Cleveland, Ohio 44121 (US) ISMAIL-BEIGI, Faramarz Cleveland, Ohio 44106 (US) (74) Representative: Abel & Imray LLP  Westpoint Building James Street West Bath BA1 2DA Bath BA1 2DA (GB)