(19)

(11)

EP 3 975 970 A1

(12)

(43) Date of publication: 06.04.2022 Bulletin 2022/14 (21) Application number: 20813099.7 (22) Date of filing: 29.05.2020

(51) International Patent Classification (IPC):  A61H 31/00(2006.01) A61B 5/05(2021.01) (52) Cooperative Patent Classification (CPC): A61H 2230/207; A61H 2230/25; A61H 31/005; A61B 5/14542; A61B 5/026 (86) International application number: PCT/US2020/035440 (87) International publication number: WO 2020/243658 (03.12.2020 Gazette 2020/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.05.2019 US 201962854215 P (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: WILSON, Robert, H. Irvine, CA 92617 (US) CROUZET, Christian Irvine, CA 92617 (US) AKBARI, Yama Irvine, CA 92617 (US) CHOI, Bernard Irvine, CA 92617 (US) TROMBERG, Bruce, J. Irvine, CA 92617 (US) (74) Representative: Budde Schou A/S  Dronningens Tvaergade 30 1302 Copenhagen K 1302 Copenhagen K (DK)