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(11)

EP 3 976 038 A1

(12)

(43) Date of publication: 06.04.2022 Bulletin 2022/14 (21) Application number: 20814821.3 (22) Date of filing: 27.05.2020

(51) International Patent Classification (IPC):  A61K 31/4725(2006.01) A61K 31/498(2006.01) A61K 31/496(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07D 519/00; C07D 487/04; A61P 31/00; C07H 19/14 (86) International application number: PCT/US2020/034711 (87) International publication number: WO 2020/243178 (03.12.2020 Gazette 2020/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 30.05.2019 US 201962854435 P 27.01.2020 US 202062966337 P (71) Applicant: Angex Pharmaceutical, Inc. North Burnswick, New Jersey 08902 (US)	(72) Inventors: WU, Wen-Lian Green Brook, NJ 08812 (US) YANG, Zhiqiang Westfield, NJ 07090 (US) LEE, Francis Yardley, PA 19067 (US) TAN, John Qiang North Brunswick, NJ 08902 (US) (74) Representative: Potter Clarkson  The Belgrave Centre Talbot Street Nottingham NG1 5GG Nottingham NG1 5GG (GB)