(19)
(11) EP 3 980 410 A1

(12)

(43) Date of publication:
13.04.2022 Bulletin 2022/15

(21) Application number: 20750715.3

(22) Date of filing: 04.06.2020
(51) International Patent Classification (IPC): 
C07D 401/12(2006.01)
C07D 401/14(2006.01)
C07D 405/14(2006.01)
C07D 417/14(2006.01)
A61K 31/506(2006.01)
A61K 31/444(2006.01)
A61K 31/4545(2006.01)
A61P 35/00(2006.01)
A61P 17/06(2006.01)
A61P 25/00(2006.01)
 C07D 403/12(2006.01)
C07D 407/14(2006.01)
C07D 417/12(2006.01)
C07D 277/52(2006.01)
A61K 31/497(2006.01)
A61K 31/351(2006.01)
A61K 31/427(2006.01)
A61P 35/02(2006.01)
A61P 37/00(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 401/14; A61P 35/00; A61P 35/02; A61P 17/06; A61P 37/00; A61P 25/00; C07D 401/12; C07D 403/12; C07D 407/14; C07D 405/14; C07D 417/12; C07D 417/14; C07D 277/52
(86) International application number:
PCT/IB2020/000560
(87) International publication number:
WO 2020/245665 (10.12.2020 Gazette 2020/50)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 04.06.2019 EP 19305714
04.06.2019 EP 19305717
04.06.2019 EP 19305715

(71) Applicant: Step Pharma S.A.S.
75272 Paris, Cedex 06 (FR)

(72) Inventors:
  • QUDDUS, Abdul
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • NOVAK, Andrew
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • COUSIN, David
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • CHATZOPOULOU, Elli
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • BLACKHAM, Emma
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • JONES, Geraint
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • THOMAS, Jennifer
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • WRIGGLESWORTH, Joseph
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • DUFFY, Lorna
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • BIRCH, Louise
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • GEORGE, Pascal
    75272 Paris Cedex 06 (FR)
  • AHMED, Saleh
    Nottingham, Nottinghamshire NG1 1GR (GB)
  • TOSCHI, Gianna
    Nottingham, Nottinghamshire NG1 1GR (GB)

(74) Representative: Goodall, Scott 
Sagittarius IP Marlow International Parkway
Marlow SL7 1YL
Marlow SL7 1YL (GB)

   


(54) N-(4-(5-CHLOROPYRIDIN-3-YL)PHENYL)-2-(2-(CYCLOPROPANESULFONAMIDO)PYRIMIDIN-4-YL) BUTANAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HUMAN CTPS1 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES