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(11)

EP 3 990 655 A1

(12)

(43) Date of publication: 04.05.2022 Bulletin 2022/18 (21) Application number: 20734888.9 (22) Date of filing: 23.06.2020

(51) International Patent Classification (IPC):  C12P 19/04(2006.01) C12P 19/18(2006.01) C12N 9/24(2006.01) A23L 33/125(2016.01) C12P 19/14(2006.01) C12N 9/10(2006.01) A61K 31/733(2006.01) A23L 29/30(2016.01) (52) Cooperative Patent Classification (CPC): C12P 19/04; C12P 19/18; C12P 19/14; C12N 9/1055; C12Y 302/01065; C12Y 204/0101; C12N 9/2402 (86) International application number: PCT/EP2020/067447 (87) International publication number: WO 2020/260249 (30.12.2020 Gazette 2020/53)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 27.06.2019 EP 19182814 (71) Applicant: Rheinische Friedrich-Wilhelms-Universität Bonn 53113 Bonn (DE)	(72) Inventors: DEPPENMEIER, Uwe 53797 Lohmar (DE) HÖVELS, Marcel 53121 Bonn (DE) KOSCIOW, Konrad 53111 Bonn (DE) (74) Representative: Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte  Hamborner Straße 53 40472 Düsseldorf 40472 Düsseldorf (DE)