(19)

(11)

EP 3 990 924 A1

(12)

(43) Date of publication: 04.05.2022 Bulletin 2022/18 (21) Application number: 20734207.2 (22) Date of filing: 25.06.2020

(51) International Patent Classification (IPC):  G01N 33/569(2006.01) A61K 47/38(2006.01) A61P 31/04(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/56916; G01N 2400/26; A61P 31/04; A61P 35/00 (86) International application number: PCT/EP2020/067795 (87) International publication number: WO 2020/260445 (30.12.2020 Gazette 2020/53)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 27.06.2019 EP 19305866 (71) Applicants: Centre national de la recherche scientifique 75016 Paris (FR) Université de Nantes 44000 Nantes (FR) Université Clermont Auvergne 63000 Clermont-Ferrand (FR)

(72) Inventors: GOUIN, Sébastien 44470 Thouare-sur-Loire (FR) FELPIN, François-Xavier 44800 Saint-Herblain (FR) SIVIGNON, Adeline 63360 Gerzat (FR) BARNICH, Nicolas 63340 Madriat (FR) (74) Representative: Novagraaf Technologies  Bâtiment O2 2, rue Sarah Bernhardt CS90017 92665 Asnières-sur-Seine Cedex 92665 Asnières-sur-Seine Cedex (FR)