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(11)

EP 3 994 127 A1

(12)

(43) Date of publication: 11.05.2022 Bulletin 2022/19 (21) Application number: 20747153.3 (22) Date of filing: 01.07.2020

(51) International Patent Classification (IPC):  C07D 231/56(2006.01) C07D 249/18(2006.01) C07D 277/22(2006.01) A01N 43/647(2006.01) A01N 43/82(2006.01) C07D 235/12(2006.01) C07D 271/06(2006.01) C07D 413/04(2006.01) A01N 43/78(2006.01) (52) Cooperative Patent Classification (CPC): C07D 231/56; C07D 235/12; C07D 271/06; C07D 277/22; C07D 249/18; C07D 413/04 (86) International application number: PCT/IL2020/050732 (87) International publication number: WO 2021/001825 (07.01.2021 Gazette 2021/01)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.07.2019 US 201962870711 P (71) Applicant: Migal Galilee Research Institute Ltd. 1101602 Kiryat Shmona (IL)	(72) Inventors: BLOCH, Itai 1383000 Ramot Naftali (IL) GAL, Maayan 3780800 Givaat Ada (IL) (74) Representative: Russell, Tim et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)