(19)
(11) EP 3 996 683 A1

(12)

(43) Date of publication:
18.05.2022 Bulletin 2022/20

(21) Application number: 20745451.3

(22) Date of filing: 08.07.2020
(51) International Patent Classification (IPC): 
A61K 9/127(2006.01)
A61K 38/18(2006.01)
A61K 48/00(2006.01)
 A61K 9/51(2006.01)
A61K 47/69(2017.01)
C12N 15/88(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 9/1272; A61K 9/5123; A61K 9/5192; A61K 9/0019; A61K 47/6929; C12N 15/88; A61K 47/544; A61K 38/00
(86) International application number:
PCT/US2020/041122
(87) International publication number:
WO 2021/007278 (14.01.2021 Gazette 2021/02)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 08.07.2019 US 201962871513 P

(71) Applicant: Translate Bio, Inc.
Lexington, MA 02421 (US)

(72) Inventors:
  • KARVE, Shrirang
    Lexington, MA 02421 (US)
  • SARODE, Ashish
    Lexington, MA 02421 (US)
  • DEROSA, Frank
    Lexington, MA 02421 (US)

(74) Representative: Elkington and Fife LLP 
Prospect House 8 Pembroke Road
Sevenoaks, Kent TN13 1XR
Sevenoaks, Kent TN13 1XR (GB)

   


(54) IMPROVED MRNA-LOADED LIPID NANOPARTICLES AND PROCESSES OF MAKING THE SAME