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EP 3 999 121 A1

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(43) Date of publication: 25.05.2022 Bulletin 2022/21 (21) Application number: 20839620.0 (22) Date of filing: 14.07.2020

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61P 3/06(2006.01) A61P 9/00(2006.01) C12N 15/861(2006.01) (52) Cooperative Patent Classification (CPC): A61P 9/00; A61P 3/06; A01K 2227/105; A01K 2217/206; A01K 2217/075; A01K 2267/03; C12N 2750/14143; C12N 2830/008; A01K 2217/15; C12N 15/86; A61K 48/005; A61K 48/0058; C07K 14/78; C12N 15/113; C12N 2310/20 (86) International application number: PCT/SG2020/050407 (87) International publication number: WO 2021/010898 (21.01.2021 Gazette 2021/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 17.07.2019 SG 10201906637U (71) Applicants: Agency for Science, Technology and Research Singapore 138632 (SG) National University of Singapore Singapore 119077 (SG)

(72) Inventors: STEWART, Colin Lawson Singapore 138648 (SG) SINGARAJA, Roshni Singapore 138648 (SG) BURKE, Brian Singapore 138648 (SG) LEE, Yin Loon Singapore 138648 (SG) TAN, Yann Chong Singapore 138672 (SG) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)