(19)

(11)

EP 4 003 348 A1

(12)

(43) Date of publication: 01.06.2022 Bulletin 2022/22 (21) Application number: 20847742.2 (22) Date of filing: 29.07.2020

(51) International Patent Classification (IPC):  A61K 31/454(2006.01) C07D 401/12(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07D 221/18; C07D 405/04; C07D 407/04; C07D 311/76; C07D 471/06; C07D 491/16; C07D 491/06; C07D 491/052; C07D 401/04; A61K 45/06 (86) International application number: PCT/US2020/044054 (87) International publication number: WO 2021/021922 (04.02.2021 Gazette 2021/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 30.07.2019 US 201962880494 P 30.07.2019 US 201962880594 P (71) Applicant: Mayo Foundation for Medical Education and Research Rochester, MN 55905 (US)	(72) Inventors: TSCHUMPERLIN, Daniel J. Rochester, Minnesota 55906 (US) HAAK, Andrew J. Rochester, Minnesota 55902 (US) (74) Representative: Fish & Richardson P.C.  Highlight Business Towers Mies-van-der-Rohe-Straße 8 80807 München 80807 München (DE)