(19)

(11)

EP 4 004 052 A1

(12)

(43) Date of publication: 01.06.2022 Bulletin 2022/22 (21) Application number: 20847569.9 (22) Date of filing: 30.07.2020

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12N 5/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/436; A61K 38/4873; A61P 37/02; C07K 16/2803; C07K 16/283; C07K 2317/31; C07K 2317/76; C07K 2317/626; A61K 2039/505; C07K 2317/94; A61K 39/39541; A61K 2039/525; A61K 2039/545; A61K 39/39; A61K 2039/577; A61K 48/0083; C12N 2750/14143; A61K 38/1774; C12Y 304/2201   C-Sets: A61K 38/1774, A61K 2300/00; A61K 38/4873, A61K 2300/00; A61K 39/39541, A61K 2300/00; A61K 31/436, A61K 2300/00; A61K 39/39, A61K 2300/00; (86) International application number: PCT/US2020/044312 (87) International publication number: WO 2021/022072 (04.02.2021 Gazette 2021/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 30.07.2019 US 201962880240 P (71) Applicant: Provention Bio, Inc. Lebanon, New Jersey 08833 (US)	(72) Inventors: LEON, Francisco Lebanon, New Jersey 08833 (US) DUNFORD, Paul Lebanon, New Jersey 08833 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)