(19)

(11)

EP 4 007 609 A1

(12)

(43) Date of publication: 08.06.2022 Bulletin 2022/23 (21) Application number: 20758033.3 (22) Date of filing: 31.07.2020

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): A61K 48/0083; A61K 48/0075; C12N 15/86; C12N 2750/14143; C12N 2800/40; C12N 2800/30; C12N 2830/002 (86) International application number: PCT/US2020/044598 (87) International publication number: WO 2021/022208 (04.02.2021 Gazette 2021/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 01.08.2019 US 201962881540 P (71) Applicant: Cornell University Ithaca, NY 14850 (US)	(72) Inventor: KAPLITT, Michael G. New York, New York 10021 (US) (74) Representative: Secerna LLP  The Old Fire Station 18 Clifford Street York YO1 9RD York YO1 9RD (GB)