(19)

(11)

EP 4 010 004 A2

(12)

(88) Date of publication A3: 11.03.2021 (43) Date of publication: 15.06.2022 Bulletin 2022/24 (21) Application number: 20851042.0 (22) Date of filing: 06.08.2020

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) C07K 19/00(2006.01) C12N 15/85(2006.01) C07K 14/195(2006.01) C12N 15/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/85; C12N 2830/005; C07K 14/7051; C07K 2319/03; C07K 2319/71; C07K 2319/81; C07K 14/70521; C07K 14/70503; C07K 14/70596; C07K 2319/80; C12N 9/22 (86) International application number: PCT/US2020/045174 (87) International publication number: WO 2021/026336 (11.02.2021 Gazette 2021/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 07.08.2019 US 201962884028 P 10.09.2019 US 201962898434 P 18.11.2019 US 201962937011 P (71) Applicant: I Altius Institute for Biomedical Sciences Seattle WA 98121 (US)

(72) Inventors: URNOV, Fyodor Seattle, Washington 98121 (US) STAMATOYANNOPOULOS, John A. Seattle, Washington 98121 (US) PEARL, Joycelynn Seattle, Washington 98121 (US) WILKEN, Matthew Seattle, Washington 98121 (US) CIARLO, Christie Seattle, Washington 98121 (US) GREEN, Shon Seattle, Washington 98121 (US) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)