(19)
(11) EP 4 010 078 A1

(12)

(43) Date of publication:
15.06.2022 Bulletin 2022/24

(21) Application number: 20852037.9

(22) Date of filing: 07.03.2020
(51) International Patent Classification (IPC): 
A61P 25/36(2006.01)
C07D 221/28(2006.01)
 C07C 229/38(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 25/36; C07D 221/28; C07C 219/22; C07D 489/08; C07D 489/02; C07D 221/26
(86) International application number:
PCT/US2020/021599
(87) International publication number:
WO 2021/029914 (18.02.2021 Gazette 2021/07)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 11.08.2019 US 201962885311 P
14.08.2019 US 201916540058

(71) Applicant: Kappa-Pharma LLC
City of Alachua, FL 32615 (US)

(72) Inventors:
  • NIKONOV, Georgiy
    Gainesville, FL 32653 (US)
  • ISAKULYAN, Levon
    New York, NY 10004 (US)
  • VORONKOV, Michael V.
    Pennington, NJ 08534 (US)

(74) Representative: Cueto, Sénida 
SP3 Patents S.L. Los Madroños, 23
28891 Velilla de San Antonio
28891 Velilla de San Antonio (ES)

   


(54) COMPOSITIONS AND METHODS OF ENHANCING OPIOID RECEPTOR ENGAGEMENT BY OPIOID HEXADIENOATES AND OPTIONALLY SUBSTITUTED HEXADIENOATES