(19)
(11) EP 4 011 915 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.11.2023 Bulletin 2023/46

(45) Mention of the grant of the patent:
11.10.2023 Bulletin 2023/41

(21) Application number: 21199451.2

(22) Date of filing: 20.08.2013
(51) International Patent Classification (IPC): 
C07K 16/28(2006.01)
A61K 39/395(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 39/39541; A61K 2039/505; A61K 2039/54; C07K 2317/21; C07K 16/2866; A61P 11/00; A61P 11/02; A61P 11/04; A61P 11/06; A61P 11/08; A61P 29/00; A61P 31/10; A61P 37/00; A61P 37/08; A61P 43/00; A61P 9/00

(54)

METHODS FOR TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-4R ANTAGONIST

VERFAHREN ZUR BEHANDLUNG ODER VERHINDERUNG VON ASTHMA DURCH VERABREICHUNG EINES IL-4R-ANTAGONISTEN

PROCÉDÉS DE TRAITEMENT OU DE PRÉVENTION DE L'ASTHME PAR ADMINISTRATION D'UN ANTAGONISTE IL-4R


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 21.08.2012 US 201261691625 P
29.01.2013 US 201361758097 P
06.02.2013 US 201361761279 P
14.03.2013 US 201361783796 P
27.03.2013 US 201361805797 P
16.07.2013 FR 1356994

(43) Date of publication of application:
15.06.2022 Bulletin 2022/24

(60) Divisional application:
23202532.0

(62) Application number of the earlier application in accordance with Art. 76 EPC:
18194745.8 / 3470432
13759908.0 / 2888281

(73) Proprietors:
  • Sanofi Biotechnology
    94250 Gentilly (FR)
  • Regeneron Pharmaceuticals, Inc.
    Tarrytown, NY 10591-6707 (US)

(72) Inventors:
  • ARDELEANU, Marius
    Tarrytown, NY 10591-6707 (US)
  • GANDHI, Namita
    Tarrytown, NY 10591-6707 (US)
  • GRAHAM, Neil
    Tarrytown, NY 10591-6707 (US)
  • KIRKESSELI, Stephane C.
    Bridgewater, NJ 08807 (US)
  • KUNDU, Sudeep
    Bridgewater, NJ 08807 (US)
  • RADIN, Allen
    Tarrytown, NY 10591-6707 (US)
  • ROCKLIN, Ross E.
    Bridgewater, NJ 08807 (US)
  • WEINSTEIN, Steven P.
    Tarrytown, NY 10591-6707 (US)
  • DAVIDSON HAMILTON, Jennifer
    Tarrytown, NY 10591-6707 (US)
  • MING, Jeffrey
    Bridgewater, NJ 08807 (US)

(74) Representative: Zwicker, Jörk 
ZSP Patentanwälte PartG mbB Hansastraße 32
80686 München
80686 München (DE)


(56) References cited: : 
WO-A1-2010/053751
   
  • J. CORREN ET AL: "A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4R Antagonist, in Patients with Asthma", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 181, no. 8, 15 April 2010 (2010-04-15), pages 788-796, XP055013586, ISSN: 1073-449X, DOI: 10.1164/rccm.200909-1448OC
  • JARED DARVEAUX ET AL: "Biologics in Asthma-The Next Step Toward Personalized Treatment", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY : AN OFFICIAL JOURNAL OF AAAAI, AMERICAN ACADEMY OF ALLERGY ASTHMA & IMMUNOLOGY, vol. 3, no. 2, 1 March 2015 (2015-03-01), pages 152-160, XP055535036, ISSN: 2213-2198, DOI: 10.1016/j.jaip.2014.09.014
  • METERAN HOWRAMAN ET AL: "Novel monoclonal treatments in severe asthma", JOURNAL OF ASTHMA : DEVOTED TO ASTHMA AND RELATED CONDITIONS, INFORMA HEALTHCARE, USA, vol. 54, no. 10, 30 November 2017 (2017-11-30), pages 991-1011, XP009510079, ISSN: 1532-4303, DOI: 10.1080/02770903.2017.1296157 [retrieved on 2017-03-16]
  • DIEGO BAGNASCO ET AL: "A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY., vol. 170, no. 2, 1 January 2016 (2016-01-01), pages 122-131, XP055535051, CH ISSN: 1018-2438, DOI: 10.1159/000447692
  • WENZEL SALLY ET AL: "Dupilumab in Persistent Asthma with Elevated Eosinophil Levels", THE NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 368, no. 26, 27 June 2013 (2013-06-27), pages 2455-2466, XP008165248, ISSN: 0028-4793, DOI: 10.1056/NEJMOA1304048 [retrieved on 2013-05-21]
   
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