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(11)

EP 4 017 592 A1

(12)

(43) Date of publication: 29.06.2022 Bulletin 2022/26 (21) Application number: 20767940.8 (22) Date of filing: 21.08.2020

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07D 237/24(2006.01) C07D 401/04(2006.01) C07D 413/14(2006.01) A61K 31/501(2006.01) A61K 31/4418(2006.01) C07D 213/82(2006.01) C07D 239/28(2006.01) C07D 403/04(2006.01) C07D 417/04(2006.01) A61K 31/506(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/04; C07D 403/04; C07D 413/14; C07D 237/24; C07D 239/28; C07D 213/82; C07D 417/04; A61P 35/00 (86) International application number: PCT/US2020/070443 (87) International publication number: WO 2021/035257 (25.02.2021 Gazette 2021/08)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.08.2019 US 201962889669 P (71) Applicant: The Scripps Research Institute La Jolla, California 92037 (US)

(72) Inventors: PETRASSI, Hank Michael James San Diego, California 92130 (US) YU, Chenguang La Jolla, California 92037 (US) WANG, Jie Shanghai 201203 (CN) CHATTERJEE, Arnab K. San Diego, California 92129 (US) ALBERO, Ana Maria Gamo San Diego, CA 92122 (US) GUPTA, Anil San Diego, California 92109 (US) TAMIYA, Junko Carlsbad, California 92011 (US) SCHULTZ, Peter G. La Jolla, California 92037 (US) JOHNSON, Kristen Santee, CA 92071 (US) CHU, Alan San Diego, CA 92129 (US) CHIN, Emily San Diego, California 92101 (US) LAIRSON, Luke L. San Diego, California 92103 (US) (74) Representative: Plougmann Vingtoft a/s  Strandvejen 70 2900 Hellerup 2900 Hellerup (DK)