(19)
(11) EP 4 017 963 A1

(12)

(43) Date of publication:
29.06.2022 Bulletin 2022/26

(21) Application number: 20764236.4

(22) Date of filing: 14.08.2020
(51) International Patent Classification (IPC): 
C12N 5/078(2010.01)
G01N 33/50(2006.01)
 A61K 35/26(2015.01)
(52) Cooperative Patent Classification (CPC):
C12N 5/065; A61K 35/26; G01N 33/5023; G01N 33/505; G01N 2800/245; G01N 2333/521; G01N 2333/5446; G01N 33/6863
(86) International application number:
PCT/US2020/046341
(87) International publication number:
WO 2021/034650 (25.02.2021 Gazette 2021/08)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 19.08.2019 US 201962888799 P
15.06.2020 US 202063039153 P

(71) Applicants:
  • Duke University
    Durham, NC 27705 (US)
  • Enzyvant Therapeutics, Inc.
    Cambridge MA 02142 (US)

(72) Inventors:
  • MARKERT, Mary Louise
    Durham, NC 27705 (US)
  • HALE, Laura P.
    Durham, NC 27705 (US)
  • TRACY, Alex
    Cambridge, MA 20142 (US)
  • MARKS, Kristin
    Cambridge, MA 20142 (US)
  • PIHEL, Karin
    Cambridge, MA 20142 (US)
  • KURTZBERG, Joanne
    Durham, NC 27705 (US)
  • CHEATHAM, Lynn
    Durham, NC 27705 (US)
  • SEMPOWSKI, Gregory D.
    Durham, NC 27705 (US)
  • MACINTYRE, Andrew N.
    Durham, NC 27705 (US)

(74) Representative: Shelton, Ruth Emily et al
Venner Shipley LLP Byron House Cambridge Business Park Cowley Road
Cambridge CB4 0WZ
Cambridge CB4 0WZ (GB)

   


(54) METHODS OF DETERMINING THE SUITABILITY OF CULTURED THYMUS TISSUE FOR IMPLANTATION INTO HUMANS AND ASSOCIATED METHODS OF USE