(19)

(11)

EP 4 021 466 A1

(12)

(43) Date of publication: 06.07.2022 Bulletin 2022/27 (21) Application number: 20938505.3 (22) Date of filing: 03.11.2020

(51) International Patent Classification (IPC):  A61K 35/28(2015.01) A61K 35/35(2015.01) C12M 3/08(2006.01) A61K 35/12(2015.01) C12M 1/02(2006.01) C12N 5/07(2010.01) (52) Cooperative Patent Classification (CPC): A61K 35/12; A61K 35/28; A61K 35/35; C12M 1/02; C12M 3/08; C12N 5/06 (86) International application number: PCT/IB2020/060324 (87) International publication number: WO 2022/096917 (12.05.2022 Gazette 2022/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (71) Applicant: The Duke Limited 22010-000 Copacabana, Rio de Janeiro (BR)	(72) Inventor: SFORZA, Marcos 22010-000 Copacabana, Rio de Janeiro (BR) (74) Representative: Style, Kelda Camilla Karen et al Page White & Farrer Bedford House John Street London, WC1N 2BF London, WC1N 2BF (GB)