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EP 4 021 518 A1

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(43) Date of publication: 06.07.2022 Bulletin 2022/27 (21) Application number: 20771716.6 (22) Date of filing: 31.08.2020

(51) International Patent Classification (IPC):  A61L 17/00(2006.01) A61L 17/10(2006.01) A61L 27/54(2006.01) A61L 27/58(2006.01) A61L 17/06(2006.01) A61L 27/18(2006.01) A61L 27/56(2006.01) (52) Cooperative Patent Classification (CPC): A61L 17/005; A61L 17/06; A61L 17/105; A61L 27/18; A61L 27/54; A61L 27/56; A61L 27/58; A61B 2017/00792; A61B 2017/00526; A61F 2002/30028; A61F 2/0063; A61B 17/06166; A61B 2017/0417; A61B 17/064; A61F 2002/3006; A61F 2002/30062; A61F 2/30721; A61F 2/30942; A61F 2002/3092; A61F 2002/2839; A61F 2/3872; A61B 2017/00004; A61F 2002/2835; A61F 2002/3093; A61F 2002/30677; A61F 2002/30766; D01F 6/62; B33Y 80/00; A61B 2017/0414; A61B 2017/00893; A61F 2002/30281; A61F 2002/30322; A61F 2/30756; A61F 2/30767; A61F 2002/30092; A61B 17/0401; A61F 2002/30838; D01F 6/84; A61F 2002/30003; A61F 2002/3096; A61F 2/2875; B33Y 70/00; A61F 2002/30985; A61F 2002/30011; A61F 2002/30736; A61B 17/07292; A61B 2017/00867; A61B 2017/00889; A61F 2/12; D01F 1/10; D01D 5/08; B29C 48/05; B29C 48/08; B29C 48/10; B29C 48/09; B29C 48/92; A61F 2/28; A61B 17/80   C-Sets: A61L 17/105, C08L 67/04; A61L 27/18, C08L 67/04; (86) International application number: PCT/US2020/048773 (87) International publication number: WO 2021/042044 (04.03.2021 Gazette 2021/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.08.2019 US 201962893565 P (71) Applicant: Tepha, Inc. Lexington, MA 02421 (US)

(72) Inventors: WILLIAMS, Simon F. Cambridge, Massachusetts 02138 (US) RIZK, Said Windham, New Jersey 03087 (US) MARTIN, David P. Arlington, Massachusetts 02474 (US) LIMEM, Skander Lynnfield, Massachusetts 01940 (US) GUO, Kai Belmont, Massachusetts 02478 (US) LOPEZ, German Oswaldo Hohl Lexington, Massachusetts 02421 (US) GANATRA, Amit Attleboro, Massachusetts 02703 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)