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(11)

EP 4 022 316 A1

(12)

(43) Date of publication: 06.07.2022 Bulletin 2022/27 (21) Application number: 20796910.6 (22) Date of filing: 20.10.2020

(51) International Patent Classification (IPC):  G01N 33/68(2006.01) A61P 25/28(2006.01) A61P 25/16(2006.01) G01N 33/50(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/16; A61P 25/28; G01N 33/5023; G01N 33/6896; G01N 2405/10; G01N 2800/28; G01N 2800/2814; G01N 2800/2835; G01N 2800/52 (86) International application number: PCT/GB2020/052632 (87) International publication number: WO 2021/079098 (29.04.2021 Gazette 2021/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.10.2019 US 201962923646 P 19.11.2019 GB 201916838 (71) Applicant: Oxford University Innovation Limited Oxford, OX2 0JB (GB)	(72) Inventors: PLATT, Frances, M. Oxford Oxfordshire OX1 3QT (GB) HALLETT, Penelope, J. Belmont, Massachusetts 02478 (US) ISACSON, Ole Belmont, Massachusetts 02478 (US) (74) Representative: Dehns  St. Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)