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EP 4 025 125 A1

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(43) Date of publication: 13.07.2022 Bulletin 2022/28 (21) Application number: 20750816.9 (22) Date of filing: 09.06.2020

(51) International Patent Classification (IPC):  A61B 5/097(2006.01) A61B 5/00(2006.01) A61B 5/08(2006.01) (52) Cooperative Patent Classification (CPC): A61B 5/082; A61B 5/097; A61B 5/4238 (86) International application number: PCT/US2020/036793 (87) International publication number: WO 2021/021299 (04.02.2021 Gazette 2021/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 26.07.2019 US 201962879345 P 10.12.2019 WO PCT/US2019/065550 (71) Applicants: Heteron Biotechnologies, LLC Setauket, New York 11733 (US) Rigas, Anastasia Setauket, New York 11733 (US)

(72) Inventors: CHIANG, Hao-Chun New York 11791 (US) LEVON, Kalle Brooklyn, New York 11238 (US) ARTAN, Nabi Sertac Brooklyn, New York 11223 (US) AMOAKO, Edward New York 11368 (US) RIGAS, Anastasia New York 11733 (US) (74) Representative: Herrero & Asociados, S.L.  Cedaceros, 1 28014 Madrid 28014 Madrid (ES)