(19)
(11) EP 4 025 212 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
16.04.2025 Bulletin 2025/16

(45) Mention of the grant of the patent:
26.02.2025 Bulletin 2025/09

(21) Application number: 20867155.2

(22) Date of filing: 25.09.2020
(51) International Patent Classification (IPC): 
A61K 31/4245(2006.01)
A61P 31/16(2006.01)
C07D 413/04(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/4245; C07D 413/12; A61K 45/06; A61P 31/16; Y02A 50/30
(86) International application number:
PCT/US2020/052773
(87) International publication number:
WO 2021/062189 (01.04.2021 Gazette 2021/13)

(54)

ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATMENT OF DISEASES CAUSED BY VIRUS INFECTION

ISOXAZOL-3-CARBOXAMIDDERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON DURCH VIRUSINFEKTION VERURSACHTEN KRANKHEITEN

DÉRIVÉS D'ISOXAZOLE-3-CARBOXAMIDE ET LEUR UTILISATION POUR LE TRAITEMENT DE MALADIES PROVOQUÉES PAR UNE INFECTION VIRALE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 27.09.2019 US 201962907231 P
19.12.2019 US 201962950546 P

(43) Date of publication of application:
13.07.2022 Bulletin 2022/28

(73) Proprietors:
  • Collaborations Pharmaceuticals, Inc.
    Raleigh, NC 27606 (US)
  • Universitätsklinikum Jena
    07747 Jena (DE)

(72) Inventors:
  • MAKAROV, Vadim
    Moscow, 115035 (RU)
  • SCHMIDTKE, Michaela
    07745 Jena (DE)
  • EKINS, Sean
    Fuquay Varina, NC 27526 (US)

(74) Representative: Isarpatent 
Patent- und Rechtsanwälte Barth Charles Hassa Peckmann & Partner mbB Friedrichstrasse 31
80801 München
80801 München (DE)


(56) References cited: : 
US-A1- 2011 065 764
US-A1- 2019 054 068
US-A1- 2012 095 002
   
  • MAKAROV VADIM A. ET AL: "Novel [(biphenyloxy)propyl]isoxazole derivatives for inhibition of human rhinovirus 2 and coxsackievirus B3 replication", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 55, no. 4, 1 April 2005 (2005-04-01), GB, pages 483 - 488, XP093060461, ISSN: 0305-7453, Retrieved from the Internet <URL:https://academic.oup.com/jac/article-pdf/55/4/483/2399776/dki055.pdf> DOI: 10.1093/jac/dki055
  • SCHMIDTKE M ET AL: "New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 81, no. 1, 1 January 2009 (2009-01-01), pages 56 - 63, XP025761847, ISSN: 0166-3542, [retrieved on 20081208], DOI: 10.1016/J.ANTIVIRAL.2008.09.002
  • CHEN YONGSHENG ET AL: "[alpha]Gal-conjugated anti-rhinovirus agents: chemo-enzymatic syntheses and testing of anti-Gal binding", ROYAL CHEMICAL SOCIETY. JOURNAL. PERKIN TRANSACTIONS 1, no. 14, 1 January 2001 (2001-01-01), GB, pages 1716 - 1722, XP093060427, ISSN: 1472-7781, DOI: 10.1039/b100356i
  • DATABASE PubChem Compound 3 May 2011 (2011-05-03), ANONYMOUS: "Compound Summary for CID 51323276", XP055806868, retrieved from NCBI Database accession no. CID 51323276
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).