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(11)

EP 4 025 596 A1

(12)

(43) Date of publication: 13.07.2022 Bulletin 2022/28 (21) Application number: 20861262.2 (22) Date of filing: 04.09.2020

(51) International Patent Classification (IPC):  C07K 14/705(2006.01) C07K 16/28(2006.01) C07K 16/24(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/248; C07K 16/2866; C07K 14/70521; C07K 2319/30; A61K 2039/505; A61K 2039/55; A61K 2039/545 (86) International application number: PCT/US2020/049422 (87) International publication number: WO 2021/046361 (11.03.2021 Gazette 2021/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 04.09.2019 US 201962895836 P (71) Applicant: Cedars-Sinai Medical Center Los Angeles, CA 90048 (US)	(72) Inventors: JORDAN, Stanley, C. Manhattan Beach, California 90266 (US) VO, Ashley Northridge, California 91326 (US) AMMERMAN, Noriko Los Angeles, California 90031 (US) HUANG, Edmund Redondo Beach, California 90278 (US) KIM, Irene Los Angeles, California 90048 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)