(19)

(11)

EP 4 025 688 A1

(12)

(43) Date of publication: 13.07.2022 Bulletin 2022/28 (21) Application number: 20772503.7 (22) Date of filing: 02.09.2020

(51) International Patent Classification (IPC):  C12N 5/0783(2010.01) (52) Cooperative Patent Classification (CPC): C12N 5/0636; C12N 2533/70; C12N 2501/515; C12N 2501/51 (86) International application number: PCT/US2020/049074 (87) International publication number: WO 2021/046134 (11.03.2021 Gazette 2021/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.09.2019 US 201962895381 P (71) Applicant: Allogene Therapeutics, Inc. South San Francisco, California 94080 (US)	(72) Inventors: NI, Yajin South San Francisco, California 94080 (US) ZHANG, Chupei South San Francisco, California 94080 (US) LEONARD, Mark W. South San Francisco, California 94080 (US) PERTEL, Thomas Charles South San Francisco, California 94080 (US) (74) Representative: Cooley (UK) LLP  22 Bishopsgate London EC2N 4BQ London EC2N 4BQ (GB)