(19)

(11)

EP 4 028 037 A1

(12)

(43) Date of publication: 20.07.2022 Bulletin 2022/29 (21) Application number: 19944875.4 (22) Date of filing: 18.11.2019

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) A61K 9/10(2006.01) C12N 15/86(2006.01) C07K 16/22(2006.01) A61P 27/02(2006.01) (52) Cooperative Patent Classification (CPC): A61P 27/02; C12N 15/86; C07K 2319/30; C07K 2319/32; C07K 16/00; A61K 38/179; C12N 2750/14143; A61K 48/005; A61K 48/0075; C12N 2710/14144 (86) International application number: PCT/US2019/062066 (87) International publication number: WO 2021/050094 (18.03.2021 Gazette 2021/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 11.09.2019 US 201962899070 P 10.10.2019 US 201962913648 P (71) Applicant: Adverum Biotechnologies, Inc. Redwood City CA 94063 (US)	(72) Inventors: GASMI, Mehdi Redwood City, California 94063 (US) KISS, Szilard Redwood City, California 94063 (US) OSBORNE, Aaron Redwood City, California 94063 (US) (74) Representative: EIP  Fairfax House 15 Fulwood Place London WC1V 6HU London WC1V 6HU (GB)