(19)
(11) EP 4 028 525 A1

(12)

(43) Date of publication:
20.07.2022 Bulletin 2022/29

(21) Application number: 20863564.9

(22) Date of filing: 07.09.2020
(51) International Patent Classification (IPC): 
C12N 15/62(2006.01)
C12N 5/00(2006.01)
A61P 35/00(2006.01)
 C07K 19/00(2006.01)
A61K 35/17(2015.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; A61K 35/17; C07K 16/2809; C07K 14/7051; C07K 2319/03; C07K 2319/33; A61K 2039/5156; C07K 2317/569; C07K 2317/31; C07K 16/30; C07K 16/32; C07K 2317/24; A61K 39/001154; A61K 39/001106; A61K 2039/5158; C12N 2510/00; C12N 5/0638; A61K 38/00; A61K 31/506; C07K 2319/00; C07K 2319/02
 
C-Sets:
A61K 31/506, A61K 2300/00;
(86) International application number:
PCT/IB2020/058302
(87) International publication number:
WO 2021/048724 (18.03.2021 Gazette 2021/11)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 12.09.2019 CN 201910866695

(71) Applicant: Biotheus (Suzhou) Co., Ltd.
Suzhou, Jiangsu 215123 (CN)

(72) Inventors:
  • LI, Zhiyuan
    Suzhou, Jiangsu 215123 (CN)
  • YI, Gang
    Suzhou, Jiangsu 215123 (CN)
  • TSUN, Andy
    Zhuhai, Guangdong 519080 (CN)
  • LIU, Xiaolin
    Zhuhai, Guangdong 519080 (CN)
  • HUANG, Weifeng
    Suzhou, Jiangsu 215123 (CN)
  • PENG, Shaogang
    Suzhou, Jiangsu 215123 (CN)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)

   


(54) COMBINED EXPRESSION OF A CHIMERIC CD3 FUSION PROTEIN AND AN ANTI-CD3-BASED BISPECIFIC T CELL ACTIVATING ELEMENT