(19)
(11) EP 4 041 294 A1

(12)

(43) Date of publication:
17.08.2022 Bulletin 2022/33

(21) Application number: 20870573.1

(22) Date of filing: 30.11.2020
(51) International Patent Classification (IPC): 
A61K 39/00(2006.01)
A61P 35/02(2006.01)
C07K 14/705(2006.01)
C12N 5/0783(2010.01)
 A61K 35/17(2015.01)
A61P 37/00(2006.01)
C07K 16/28(2006.01)
C12N 5/10(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 14/705; C07K 14/70575; C07K 14/70578; A61K 39/001117; A61P 37/00; A61P 35/02; A61K 2039/5156; C07K 2319/03; C07K 2319/33; C07K 16/2803; C12N 2510/00; C12N 5/0636; A61K 38/00; A61K 35/17
(86) International application number:
PCT/IB2020/061294
(87) International publication number:
WO 2021/064718 (08.04.2021 Gazette 2021/14)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 01.10.2019 US 201962908795 P
24.02.2020 US 202062980727 P
01.06.2020 US 202016888989

(71) Applicant: CASE WESTERN RESERVE UNIVERSITY
Cleveland, Ohio 44106 (US)

(72) Inventor:
  • PARAMESWARAN, Reshmi
    Cleveland, Ohio 44106 (US)

(74) Representative: Brand Murray Fuller LLP 
50 Eastcastle Street
London W1W 8EA
London W1W 8EA (GB)

   


(54) TARGETING B CELL ACTIVATING FACTOR RECEPTOR (BAFF-R) USING LIGAND-BASED CHIMERIC ANTIGEN RECEPTOR (CAR)-T CELLS