(19)

(11)

EP 4 045 054 A1

(12)

(43) Date of publication: 24.08.2022 Bulletin 2022/34 (21) Application number: 20876826.7 (22) Date of filing: 14.10.2020

(51) International Patent Classification (IPC):  A61K 31/56(2006.01) A61K 47/55(2017.01) C07H 9/00(2006.01) A61K 47/54(2017.01) C07H 1/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/554; A61K 47/6911; A61K 47/6923; A61K 47/6929; A61K 47/542; A61K 45/06; A61K 31/136; A61K 31/555; A61K 31/282; A61K 31/704; A61K 31/405; A61K 31/58; C07J 43/003   C-Sets: A61K 31/405, A61K 2300/00; A61K 31/58, A61K 2300/00; A61K 31/136, A61K 2300/00; A61K 31/555, A61K 2300/00; A61K 31/282, A61K 2300/00; A61K 31/704, A61K 2300/00; (86) International application number: PCT/US2020/055585 (87) International publication number: WO 2021/076630 (22.04.2021 Gazette 2021/16)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.10.2019 US 201962914950 P 18.11.2019 US 201916687368 (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: MEI, Kuo-Ching Oakland, CA 94607-5200 (US) MENG, Huan Oaklanc, CA 94607- 5200 (US) NEL, Andre E. Oakland, CA 94607-5200 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)