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EP 4 058 033 A1

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(43) Date of publication: 21.09.2022 Bulletin 2022/38 (21) Application number: 20824631.4 (22) Date of filing: 12.11.2020

(51) International Patent Classification (IPC):  A61K 35/15(2015.01) C07K 14/47(2006.01) A61P 1/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/4702; A61P 1/00; A61K 35/15; A61K 38/00 (86) International application number: PCT/IB2020/060674 (87) International publication number: WO 2021/094983 (20.05.2021 Gazette 2021/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 12.11.2019 US 201962934299 P (71) Applicant: Oxford University Innovation Limited Botley Oxford OX2 0JB (GB)

(72) Inventors: NANCHAHAL, Jagdeep Oxford Oxfordshire OX3 8FE (GB) VINALS GUITART, Alvaro Oxford Oxfordshire OX2 0JB (GB) YUE, Wyatt Oxford Oxfordshire OX3 8FE (GB) BURGESS-BROWN, Nicola Oxford Oxfordshire OX13 6PU (GB) LEE, Tzung Yuan Oxford Oxfordshire OX2 0JB (GB) ESPIRITO SANTO, Ana Isabel Oxford Oxfordshire OX2 0JB (GB) (74) Representative: Kransell & Wennborg KB  P.O. Box 27834 115 93 Stockholm 115 93 Stockholm (SE)