(19)

(11)

EP 4 058 145 A1

(12)

(43) Date of publication: 21.09.2022 Bulletin 2022/38 (21) Application number: 20828839.9 (22) Date of filing: 12.11.2020

(51) International Patent Classification (IPC):  A61P 25/02(2006.01) C07D 207/06(2006.01) C07D 211/14(2006.01) C07D 211/46(2006.01) C07D 277/32(2006.01) C07D 295/205(2006.01) C07D 333/24(2006.01) C07D 401/12(2006.01) C07D 471/08(2006.01) A61P 25/28(2006.01) C07D 209/08(2006.01) C07D 211/38(2006.01) C07D 217/04(2006.01) C07D 295/04(2006.01) C07D 333/18(2006.01) C07D 333/70(2006.01) C07D 409/04(2006.01) (52) Cooperative Patent Classification (CPC): C07D 295/04; C07D 333/18; C07D 471/08; C07D 409/04; C07D 333/70; C07D 295/205; C07D 211/46; C07D 211/38; C07D 211/14; C07D 207/06; C07D 209/08; C07D 217/04; C07D 277/32; C07D 333/24; C07D 401/12; A61P 25/02; A61P 25/28 (86) International application number: PCT/IB2020/060659 (87) International publication number: WO 2021/094974 (20.05.2021 Gazette 2021/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 13.11.2019 EP 19208888 (71) Applicant: Libra Therapeutics, Inc. San Diego, CA 92121 (US)	(72) Inventors: PEVARELLO, Paolo 20091 Bresso (MI) (IT) CUSANO, Valentina 20091 Bresso (MI) (IT) SODANO, Mariangela 20091 Bresso (MI) (IT) TORINO, Domenica 20091 Bresso (MI) (IT) VITALONE, Rocco 20091 Bresso (MI) (IT) LIBERATI, Chiara 20091 Bresso (MI) (IT) PISCITELLI, Francesco 20091 Bresso (MI) (IT) (74) Representative: Bianchetti & Minoja SRL  Via Plinio, 63 20129 Milano 20129 Milano (IT)