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EP 4 058 578 A2

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(88) Date of publication A3: 17.06.2021 (43) Date of publication: 21.09.2022 Bulletin 2022/38 (21) Application number: 20820673.0 (22) Date of filing: 12.11.2020

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 35/74(2015.01) C12N 15/117(2010.01) A61K 39/00(2006.01) A61P 35/00(2006.01) C12N 1/36(2006.01) C07K 14/47(2006.01) A61K 38/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 1/36; A61K 35/74; A61P 35/00; C07K 14/4705; A61K 38/00; A61K 31/7088; A61K 35/28; A61K 35/17; A61K 2039/523; A61K 2039/572; A61K 2039/82; A61K 39/00114; A61K 39/001141 (86) International application number: PCT/US2020/060307 (87) International publication number: WO 2021/097144 (20.05.2021 Gazette 2021/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 12.11.2019 US 201962934503 P 16.01.2020 US 202062962162 P 16.03.2020 US 202062990404 P (71) Applicant: Actym Therapeutics, Inc. Berkeley, CA 94710 (US)

(72) Inventors: THANOS, Christopher, D. Tiburon, CA 94920 (US) GLICKMAN, Laura, Hix Oakland, CA 94611 (US) IANNELLO, Alexandre, Charles, Michel Oakland, CA 94618 (US) RAE, Chris Richmond, CA 94805 (US) KEHOE, Haixing Berkeley, CA 94709 (US) PETERSON, Bret, Nicholas Oakland, CA 94602 (US) CHEUNG, Chingnam Oakland, CA 94619 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)