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(11)

EP 4 065 108 A1

(12)

(43) Date of publication: 05.10.2022 Bulletin 2022/40 (21) Application number: 20893667.4 (22) Date of filing: 25.11.2020

(51) International Patent Classification (IPC):  A61K 31/4188(2006.01) A61K 47/02(2006.01) A61K 31/495(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/495; A61K 9/0053; A61K 47/14; A61K 47/22; A61P 35/00; A61K 31/444; A61K 31/09   C-Sets: A61K 31/495, A61K 2300/00; A61K 31/444, A61K 2300/00; A61K 31/09, A61K 2300/00; (86) International application number: PCT/US2020/062288 (87) International publication number: WO 2021/108601 (03.06.2021 Gazette 2021/22)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 25.11.2019 US 201962939823 P 21.09.2020 US 202063081098 P (71) Applicants: The Johns Hopkins University Baltimore, Maryland 21218 (US) Academia Sinica Taipei 11529 (TW) National Chiao Tung University Hsinchu City 30010 (TW)

(72) Inventors: HUANG, Ru Chih C. Baltimore, Maryland 21218 (US) CHUN, Jong Ho Baltimore, Maryland 21218 (US) LIN, Yu-Ling Taipei, 11529 (TW) LIANG, Yu-Chuan Taipei, 11529 (TW) LIAO, Kunag-Wen Hsinchu City, 30010 (TW) JACKSON, Tiffany Baltimore, Maryland 21218 (US) MOLD, David Baltimore, Maryland 21218 (US) LAI, Chien-Hsien Baltimore, MD 21218 (US) (74) Representative: Murgitroyd & Company  Murgitroyd House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)