(19)

(11)

EP 4 065 687 A1

(12)

(43) Date of publication: 05.10.2022 Bulletin 2022/40 (21) Application number: 20891717.9 (22) Date of filing: 27.11.2020

(51) International Patent Classification (IPC):  C12M 3/00(2006.01) (52) Cooperative Patent Classification (CPC): C12M 41/46; C12M 23/34; C12M 23/20 (86) International application number: PCT/SG2020/050698 (87) International publication number: WO 2021/107879 (03.06.2021 Gazette 2021/22)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 27.11.2019 SG 10201911272X (71) Applicants: Agency for Science, Technology and Research Singapore 138632 (SG) National University of Singapore Singapore 119077 (SG)

(72) Inventors: YU, Hanry Singapore 138669 (SG) UNADKAT, Hemant Viiavkumar Singapore, 5A Engineering Drive 1, Singapore 117411 (SG) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)