(19)

(11)

EP 4 072 457 A1

(12)

(43) Date of publication: 19.10.2022 Bulletin 2022/42 (21) Application number: 20899590.2 (22) Date of filing: 09.12.2020

(51) International Patent Classification (IPC):  A61B 18/18(2006.01) A61B 18/04(2006.01) A61N 7/02(2006.01) A61B 18/00(2006.01) A61N 5/02(2006.01) (52) Cooperative Patent Classification (CPC): A61N 7/02; A61B 18/1815; A61B 2018/00529; A61B 2018/00577; A61B 18/06; A61B 18/1477; A61B 2018/00613; A61B 2218/002; A61B 90/37; A61B 2090/374; A61B 2090/3762; A61B 2090/378 (86) International application number: PCT/US2020/064082 (87) International publication number: WO 2021/119173 (17.06.2021 Gazette 2021/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 09.12.2019 US 201916708416 (71) Applicants: Rhode Island Hospital Providence, RI 02903 (US) Brown University Providence, RI 02912 (US)	(72) Inventors: PARK, William, Keun Chan Westerly, RI 02891 (US) DUPUY, Damian, E. Centerville, MA 02632 (US) (74) Representative: Wilson Gunn  Blackfriars House The Parsonage 5th Floor Manchester M3 2JA Manchester M3 2JA (GB)